Kooky Monday: Potatoes contain diazepam

POTATOES contain DIAZEPAM !!! MOTHER NATURE is mad...
« on: March 12, 2017, 04:05:53 pm »

Hi All,
i put what i have read
is it true?? if YES i won’t eat potatoes anymore for years !!  

post @ poppies.org

“We must be talking the atropa alkaloids right? No….not really…in the last few years it was noticed that plants such as wheat and potatoes accumulated benzodiazepines…more recently it was demonstrated that sterile plant cultures (Solanum tuberosum and Artemesia dracunculus) are capable of synthesizing various 5-phenyl-1,4-benzodiazepines (the pharmacologically active type) including diazepam, N-desmethyldiazpam, delorazepam, delorazepam, lorazepam etc…(see Kavvadias et al, 2000 Biochem Biophys Res Comm 269:290) thus indicating that the plant (and not some bacterial or fungal contaminant) is producing these compounds. In this paper, they culture a number of plants in sterile conditions including potato (Solanum tuberosum) and French tarragon (Artemesia dracunculus) and then identified the presence of these compounds using benzodiazepine receptor assays (using brain membranes) and via preparative HPLC-ESI- MS/MS using known benzodiazepine standards for comparison. So it seems pretty certain that these plants really are producing these compounds (albeit in low amounts – for example temazepam was found at 100-450 ng/g FW in potato cultures). The pathway to these compounds is also totally unknown really…it has been suggested that a pathway similar to that found in penicillium leading to cyclopeptine and utilizing anthranilate, tyrosine and glycine to form the benzo skeleton is responsible for their formation at least in these fungi…i have my suspicions that the whole pathway is based on benzoic acid, glycine and anthranilate in plants however, with a mechanism similar to that used in the biosynthesis of tryptophan…anyways…

does anyone else want to put in their two cents on this?

can we start engineering potatoes to produce benzos?

Not that i really consider the benzos to be sacramental in anyway, but i don’t know what other forum to post this in…”

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