Doctors defend benzodiazepines

This brief editorial is a statement to introduce a new working group on benzodiazepines, the International Task Force on Benzodiazepines, which comprises independent scientists, clinical researchers, and clinical psychopharmacologists. No references are included here as it would be beyond the scope and goal of this introduction, but a full review on benzodiazepines will be the topic of a number of papers and presentations in the near future.

Benzodiazepines have been with us since the dawn of modern psychopharmacology. Chlordiazepoxide, the first benzodiazepine, was discovered by Leo Sternbach in the late 1950s and was approved for use in the USA in 1960. Sternbach, a genial chemist, also discovered several other benzodiazepines, such as clonazepam, diazepam, flurazepam, flunitrazepam, and nitrazepam.

Benzodiazepines quickly became popular and widely used due to their versatility, tolerability, and ease of use. As they have anxiolytic, anticonvulsant, hypnotic, muscle relaxant, and sedative properties, they have been used widely and remain the most widely prescribed psychotropic medications among all medical specialties. Psychiatrists have been using benzodiazepines for the treatment of anxiety disorders, insomnia, alcohol withdrawal, and as adjunct therapy for many other indications since their discovery. The anxiolytic properties of benzodiazepines are still unsurpassed by other psychotropic medications, such as antidepressants and antipsychotics that are used in the treatment of anxiety disorders and anxiety symptoms in other mental disorders. Their adverse effect profile is relatively benign, with sedation and possible cognitive impairment being noted most frequently.

In spite of the unquestionable benefits of benzodiazepines and their popularity among physicians of various disciplines, we have witnessed a fairly negative campaign against benzodiazepines, which are often described as being readily abused (although their abuse liability is low and, if abuse occurs, it is in the context of other substance abuse). Interestingly, this campaign has intensified since the advent of selective serotonin reuptake inhibitors (SSRIs) in the mid-1990s. The SSRIs, originally approved for the treatment of depressive disorders, were quickly approved for various anxiety disorders despite the lack of sufficient evidence (i.e., comparison to the existing efficacious anxiolytic drugs, benzodiazepines), and they are now promoted as the first-line treatment for these disorders. In addition, the scientific literature has gradually and surreptitiously been flooded with more and more articles on “negative” properties of benzodiazepines. While many of these publications have either not been based on good science or been frankly biased, they easily achieved a common goal that negative propaganda frequently reaches: they aroused suspicion of benzodiazepines and suggested difficulties in using them, while overlooking their benefits. An “illusion of truth” effect then occurred as frequently repeated negative information and half-truths gradually became the truth as benzodiazepines were given a “bad” name and their reputation was damaged, especially in some scientific circles. Even prescribing these drugs has become a cumbersome procedure around the world.

The International Task Force on Benzodiazepines, as a group of investigators and clinical psychopharmacologists with long-standing clinical and scientific expertise, has been concerned about this excessively negative trend. We feel that benzodiazepines have not been given proper attention during the last 2–3 decades, they have not been adequately compared to other psychotropic medications in various indications, and their risks and side effects have been overemphasized. Some of us feel that benzodiazepines have been the subject of an unspoken “commercial war.”

This Task Force will be working on presenting various psychiatric and medical audiences with information about benzodiazepines which is evidence based, balanced, unbiased, and clinically relevant and useful. We believe that our colleagues deserve such information as it will encourage our common goal of treating our patients effectively, properly, and safely. We hope to preserve benzodiazepines as a valuable part of our armamentarium.

6 thoughts on “Doctors defend benzodiazepines

  1. And you would give this horrible torturous poison to your own child or spouse?
    Would you take this yourself? For months and years?
    You are a bunch of psychopathic malignant narcissists.

  2. Of course doctors are going to defend it because they were taught in medical school that this class of drugs isn’t harmful which now is being revealed that isn’t true. These class of drugs cause brain damage and severe central nervous system damage. Just look up the toxicology reports of the last 20 years of celebs. The majority are on benzos. That isn’t a coincidence. Many of us were misdiagnosed and told our symptoms were something else. Justin Beiber was recently diagnosed with CFS and Lyme Disease. I was too in the 00’s. It wasn’t Lyme or CFS because no doctor knew that the central nervous system depressant was slowly damaging my organs (brain and liver even though I never drink.) You clearly have a issues and want to take vengeance on those who want to expose what these drugs actually do to people and how the manufacturers systematically altered studies since the 1960’s, knowing that these drugs were harmful and cause severe brain damage.

  3. Would you please cite medical literature – not some kook on Facebook, Benzo Buddies, Twitter etc. – that proves benzodiazepines cause brain damage? Celebrity deaths, associated with benzodiazepines, are totally meaningless, as most of them were polydrug abusers. In addition, there are not many, if any, deaths from an overdose of benzodiazepines. Deaths associated with benzodiazepines are of people who mixed them with other drugs i.e. opiates, alcohol, etc. People who take more benzodiazepines than their doctor prescribed usually become drowsy, and fall asleep – then they wake up.

    The most mentally healthy thing you can do for yourself is get away, run away, from cult sites, like Benzo Buddies, before the brainwashing becomes more severe.

  4. Amen to staying away from the cult sites. BenzoBuddies is the worst. We all know that benzos are hard to come off. We all know that when you come off you will experience anxiety and panic like you cannot imagine and we all know the only thing that can help is time, patience and learning how to cope and quite possibly a different drug. This requires a change in thinking and not just blaming big pharma(as they like to use this phrase a lot).

  5. william smith – How do we all know “that benzos are hard to come off. We all know that when you come off you will experience anxiety and panic like you cannot imagine and we all know the only thing that can help is time, patience and learning how to cope and quite possibly a different drug”. I didn’t know any of that until I came across Benzo Buddies. That’s even after a week in a psych hospital and later 30 days in a rehab center. The only part of that I was told was “quite possibly a different drug”. And that certainly didn’t work. Six years later, I can attest to what you say (except for the different drug part). How could I have found this information sooner? Serious question.

  6. David – You’re right about the information on that site. There is a lot of it but there is also a lot of bad information on that site and I still have no idea what the moderators are trying accomplish. They do feel like a cult to me with the ashton manual being their one and only bible.

    I do know people also get addicted to reading about the misery of others. Misery loves company but at some point that stops being helpful.

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